The Ann Sothern Show is an American sitcom starring Ann Sothern that aired on CBS for 93 episodes. The series began on October 6, 1958, and ended on September 25, 1961.

The Ann Sothern Show was Sothern's second sitcom for CBS. Her first series, Private Secretary, ended in 1957 after a contract dispute occurred between Sothern and Secretary's producer Jack Chertok. Several of Private Secretary's cast members appeared in the show.